Under is a transcript of correspondent Dr. Jon LaPook’s conversation with 60 Minutes Overtime’s Ann Silvio about his story this week on a gene therapy trial that could be a get rid of for sickle mobile anemia.
ANN SILVIO: Jon, you reported on a health-related breakthrough on sixty Minutes this 7 days. How important is this for sickle cell anemia?
DR. JON LAPOOK: I imagine it is a significant offer — it really is a proof of idea. It states, “We can in fact do this.” We can fiddle with the genes and we can overcome anyone with sickle mobile anemia.
DR. JON LAPOOK: Are you daring to say you will find a cure for sickle cell anemia with this cure?
DR. FRANCIS COLLINS: I am daring to say a treatment for sickle mobile condition may even be now at hand.
ANN SILVIO: Was there a voice in your head that was telling you, “Permit him say the phrase “overcome”, I am not gonna say it.”
DR. JON LAPOOK: Oh, I would by no means have stated the term “get rid of.” We are men and women of science, but you you should not want to jinx it, you know? Like, okay, if we do not say it– but yeah, I assume– from every thing that it appears to be like, it seems like a remedy. And for me, it can be primarily psychological since from 1976 to 1986 — ten a long time when I was looking at a ton of individuals who had sickle mobile anemia. And I could explain to you their names however, but I won’t for HIPAA motives. But one immediately after the other, they died.
ANN SILVIO: You couldn’t aid them?
DR. JON LAPOOK: All you could do was give them soreness medication. So it was a quite helpless emotion. So I was taught first, it was, like, the to start with month of health-related college “Someday we are gonna have a treatment for sickle cell anemia.” That was 1976. And so for me to see that– that patient, suitable in entrance of my eyes, who’s treated.
ANN SILVIO: You might be conversing about Jennelle Stephenson?
DR. JON LAPOOK: Jennelle Stephenson
ANN SILVIO: So when you began reporting this story, did you know what the outcome was gonna be, that this would be successful?
DR. JON LAPOOK: Not at all, in truth I didn’t know if it was gonna get the job done. Jennelle hadn’t gotten any treatment method nonetheless. Her whole daily life she’s been a unwell individual.
JENNELLE STEPHENSON: It is really a quite sharp, like, stabbing, almost feels like bone-crushing soreness.
DR. JON LAPOOK: She imagined she was gonna die early. She had a ton of good friends who died early.
DR. JON LAPOOK: You just feel so delighted.
JENNELLE STEPHENSON: I am, I am, I seriously am.
ANN SILVIO: She’s specified up factors while. I realize she’s presented up the decision to have children.
DR. JON LAPOOK: Ideal. That was section of the chemotherapy.
DR. JON LAPOOK: What was stated to you about the possible side consequences?
JENNELLE STEPHENSON: That my reproductive procedure would have been variety of wiped out from the chemo–
DR. JON LAPOOK: Endlessly?
JENNELLE STEPHENSON: Yes. So– of course. I just, I arrived to conditions with it for the reason that, to be honest, I wouldn’t want a child with sickle cell anyway, it can be a truly rough sickness, and I would under no circumstances want to see an offspring go by way of it.
DR. JON LAPOOK: And she also risked her lifestyle to even go by this.
ANN SILVIO: 60 Minutes has aired tales about the dangers of altering genes– messing with the human genome. Is that concern component of this tale?
DR. JON LAPOOK: Yes. Since no issue how you might be performing it– I imply, you are fiddling with the genes of a human being. As soon as you place that gene into anyone, you won’t be able to un-set that gene into somebody, at the very least not now. In the foreseeable future they speak about owning a eliminate switch, so that if items go mistaken you can somehow flip the gene off. But which is just one of the huge fears and there have been real calamities. Loss of life from gene therapy in the earlier. Very well, you discuss to Jennelle, she knew all this.
DR. JON LAPOOK: This is extravagant genetic tinkering. And it entails placing various sort of genes within of you that you typically you should not have.
JENNELLE STEPHENSON: Proper.
DR. JON LAPOOK: Does that give you any pause?
JENNELLE STEPHENSON: I was terrified at initially. I feel they were being using the HIV virus or a thing, just due to the fact it spreads so perfectly.
DR. JON LAPOOK: Proper, a weakened HIV virus.
JENNELLE STEPHENSON: Proper. Of training course. Of system.
DR. JON LAPOOK: That wouldn’t give you HIV.
JENNELLE STEPHENSON: Of class. Of program.
ANN SILVIO: For any individual who was all around throughout the HIV epidemic, you know, heading back again to the ’80s–
DR. JON LAPOOK: March of 1981. My first individual with HIV. Very first bed on the left in the intense care device.
ANN SILVIO: So now you’re executing a 60 Minutes tale and HIV is really the secret weapon to curing illness–
DR. JON LAPOOK: It can be wonderful. Just isn’t that awesome. This is a excellent example of why you have to set income into simple investigation. Who would have regarded that figuring out how the HIV virus works would enable you almost certainly get rid of sickle mobile anemia someday? We do not know what we are gonna use. We are building up all these tools, we’re carrying out all this fundamental research. If I someday create some condition, I am gonna want a treatment for that or a great treatment for it that working day. Properly, it usually takes ten, twenty, 30 several years it’s possible to occur up with that. So, when I see Jennelle, encapsulated in Jennelle and in her results– is so considerably.
JENNELLE STEPHENSON: These are the variety of issues I have usually wished to do. Just an evening stroll. Very little to it….
For a lot more data about the NIH clinical demo:
The trial carries on to enroll new people with sickle mobile anemia. To discover additional about joining this demo and other folks at the NIH visit www.cc.nih.gov/recruit or connect with 1-800-411-1222.
The video earlier mentioned was manufactured by Ann Silvio and Lisa Orlando. It was edited by Lisa Orlando.
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